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Description (Français)


L’alprazolam est une benzodiazépine anxiolytique utilisée pour traiter les troubles de l’anxiété.

Mécanisme d’action
Alprazolam augmente l’action cérébrale du GABA, acide gamma amino butyrique, un neurotransmetteur inhibant l’activité cérébrale

Pharmacocinétique
L’alprazolam est bien absorbé au niveau du tube digestif. La concentration plasmatique maximum est atteinte au bout de 1-2 heures. La substance est principalement liée aux protéines plasmatiques, surtout l’albumine. Dans le foie, l’alprazolam est hydroxylé en α-hydroxyalprazolam, qui est également actif. Cette dernière molécule, ainsi que les autres métabolites sont plus tard excrétés dans l’urine sous forme de glucuronides. Une partie de l’alprazolam est également excrétée telle quelle.
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