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Descrição (Português)


Alprazolam é uma substância utilizada como medicamento pertencente ao grupo e sub-grupos:

Indicações Terapêuticas
— Perturbações da ansiedade e sintomas ansiosos.
— Ataques de pânico.

Reacções adversas
— Sonolência.
— Descoordenação motora.
— Alterações gastro-intestinais.
— Diarreia.
— Vómitos.
— Alterações do apetite.
— Alterações visuais.
— Irregularidades cardiovasculares.
— Alteração da memória.
— Confusão.
— Depressão.
— Vertigem.

Contra indicações e precauções
— As doses devem ser reduzidas nos idosos.
— Deve ser administrado com cuidado em doentes com miostenia gravis ou insuficiência respiratória ou com apneia do sono.
— Não deve ser administrado em doentes com porfiria.
— Não deve ser inalado e deve ser evitado o contacto com a pele.

Interacções
Deve ser evitado o uso concomitante de álcool e medicamentos depressores do Sistema Nervoso Central.

Posologia
— Apresentações: comprimidos de 0,25 mg, 0,5 mg, 1,0 mg ou 2,0 mg de alprazolam.
— A posologia mais frequente é de 0,25 mg ou 0,5 mg administrada de acordo com orientação médica.

Farmacocinética
— Alprazolam atravessa a barreira placentária e aparece em pequenas doses no leite materno (cerca de 3% da dose ingerida pela mãe)
— A meia-vida da alprazolam é de cerca de 11,4 horas nos indivíduos saudáveis e cerca de 19,7 horas em indivíduos com cirrose hepática.
— O pico de maior concentração no plasma é obtido ao fim de uma ou duas horas após a ingestão.
— 70% a 80 % de alprazolam liga-se às proteínas plasmáticas
— É metabolizado no fígado, dando origem ao metabolito hidroxialprazolam que tem cerca de metade da ação do alprazolam.

Excreção
— Alprazolam é excretado pela urina, assim como os seus metabolitos.
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